An autoimmune condition called scleroderma results in inflammation and fibrosis, or thickening, of the skin and other bodily tissues. Scleroderma develops when an immune reaction misleads tissues into believing they are damaged, resulting in inflammation and excessive production of collagen by the body. Tight, hard spots on your skin are caused by an excess of collagen in your skin and other tissues. Numerous bodily systems may be impacted by scleroderma. Numerous bodily systems are impacted by systemic sclerosis, commonly known as systemic scleroderma. This is a more severe form of scleroderma that can harm internal organs like the kidneys, lungs, and heart as well as blood vessels. There is no recognized cause of scleroderma. Nonetheless, scientists believe that an overreaction by the immune system results in inflammation and damage to the blood vessel lining cells. This leads to an overproduction of collagen and other proteins by connective tissue cells, particularly fibroblasts. An accumulation of collagen in the skin and other organs as a result of the fibroblasts' prolonged life span than usual causes some of the scleroderma symptoms. Blood vascular damage is another possibility.
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